The lyophilized powder GENOTROPIN contains somatropin, which is a polypeptide hormone of recombinant DNA origin. It has 191 amino acid residues and a molecular weight of 22,124 daltons. The amino acid sequence of the product is identical to that of human growth hormone of pituitary origin (somatropin). GENOTROPINE is synthesized in a strain of Escherichia coli that has been modified by adding the gene for human growth hormone. GENOTROPIN is a sterile white lyophilised powder for subcutaneous injection.
GENOTROPIN 5 mg is distributed in a two-chamber cartridge. The front chamber contains 5.8 mg recombinant somatropin, 2.2 mg glycine, 1.8 mg mannitol, 0.32 mg anhydrous sodium dihydrogen phosphate and 0.31 mg anhydrous disodium phosphate; the back chamber contains 0.3% m-Cresol (as a preservative) and 45 mg mannitol in 1.14 ml water for injection. The GENOTROPIN 5 mg double-cartridge cartridge contains 5.8 mg somatropin. The reconstituted concentration is 5 mg / ml. The cartridge contains an overflow to allow delivery of 1 ml containing the declared amount of GENOTROPIN – 5 mg.
GENOTROPIN 12 mg is distributed in a two-chamber cartridge. The front chamber contains recombinant somatropin 13.8 mg, glycine 2.3 mg, mannitol 14.0 mg, anhydrous sodium dihydrogen phosphate 0.47 mg and anhydrous disodium phosphate 0.46 mg; the back chamber contains 0.3% m-Cresol (as a preservative) and 32 mg mannitol in 1.13 ml water for injections. The GENOTROPIN 12 mg dual-cartridge cartridge contains 13.8 mg somatropin. The reconstituted concentration is 12 mg / ml. The cartridge contains an overflow to allow delivery of 1 ml containing the declared amount of GENOTROPIN – 12 mg.
GENOTROPIN MINIQUICK® is distributed as a disposable syringe device containing a two-chamber cartridge. GENOTROPIN MINIQUICK is available as individual doses of 0.2 mg to 2.0 mg in steps of 0.2 mg. The front chamber contains recombinant somatropin 0.22 to 2.2 mg, glycine 0.23 mg, mannitol 1.14 mg, sodium dihydrogen phosphate 0.05 mg and anhydrous disodium phosphate 0.027 mg; the rear chamber contains 12.6 mg mannitol in water for injections 0.275 ml. The GENOTROPIN MINIQUICK two-chamber reconstituted cartridge contains overflow to allow delivery of 0.25 ml containing the amount indicated by GENOTROPIN.