Description
Tamoxifen citrate is a type of hormone therapy called a selective estrogen receptor modulator (or SERM). It works by binding to estrogen receptors, blocking estrogen’s effects in some tissues while mimicking its effects in others. In breast tissue, tamoxifen citrate blocks estrogen from binding to its receptors, which may prevent the growth of cancer cells. Tamoxifen citrate mimics estrogen’s effects in bone tissue, which may reduce bone resorption and turnover and increase bone mineral density.
Tamoxifen citrate is approved to treat:
- Breast cancer in women and men. It is used:
- in patients whose cancer has spread to other parts of the body
- as adjuvant therapy in women whose cancer was treated with surgery and radiation therapy
- Ductal carcinoma in situ (DCIS). It is used to decrease the chance of invasive breast cancer in women who have had surgery and radiation therapy for DCIS.
Tamoxifen citrate is also approved to prevent:
- Breast cancer in women who are at high risk for the cancer.
Tamoxifen citrate is also being studied in the treatment of other types of cancer.
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